Phosphopantothenate—cysteine ligase

phosphopantothenate-cysteine ligase
Identifiers
EC number 6.3.2.5
CAS number 9023-50-1
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / EGO

In enzymology, a phosphopantothenate-cysteine ligase (EC 6.3.2.5) is an enzyme that catalyzes the chemical reaction

CTP + (R)-4'-phosphopantothenate + L-cysteine \rightleftharpoons CMP + diphosphate + N-[(R)-4'-phosphopantothenoyl]-L-cysteine

The 3 substrates of this enzyme are CTP, (R)-4'-phosphopantothenate, and L-cysteine, whereas its 3 products are CMP, diphosphate, and [[N-[(R)-4'-phosphopantothenoyl]-L-cysteine]].

This enzyme belongs to the family of ligases, specifically those forming carbon-nitrogen bonds as acid-D-amino-acid ligases (peptide synthases). The systematic name of this enzyme class is (R)-4'-phosphopantothenate:L-cysteine ligase. This enzyme is also called phosphopantothenoylcysteine synthetase. This enzyme participates in pantothenate and coa biosynthesis.

Structural studies

As of late 2007, 5 structures have been solved for this class of enzymes, with PDB accession codes 1P9O, 1U7U, 1U7W, 1U7Z, and 1U80.

References